Quinone and hydroquinone lipids
Medchemexpress LLC ATIC-IN-1 acetate | 3067165-96-9 | C23H37N7O7 | 25 MG
ATIC-IN-1 acetate, also known as compound 14, is an inhibitor that targets the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). This dimerization is crucial for the AICAR transformylase activity of ATIC, which plays a role in de novo purine biosynthesis. It demonstrates anti-tumor activity by reducing cell numbers and cell division rates.
- Inhibits ATIC dimerization with a Ki value of 685 nM
- Exhibits anti-tumor activity
- Reduces cell numbers and cell division rates
- Can be used in research to study ATIC dimerization and its role in purine biosynthesis and tumor proliferation
- Inhibits the proliferation of MCF-7 cells at concentrations of 100-500 μM over 48 hours
- At 250 μM for 24-72 hours, it reduces cell division rather than increasing cell death
Medchemexpress LLC Endoxifen (E-isomer) | 114828-90-9 | 98.0% | 373.49 | 100 MG
Endoxifen E-isomer (E-Endoxifen) is an impurity in Endoxifen Z-isomer, exhibiting antiestrogenic effects. It is intended for research use only.
- Inhibits PGR gene expression in E2-induced MCF-7 cells
- Suitable for in vitro biological activity studies
- Provided as a solid for various experimental applications
Medchemexpress LLC MAIT-203 (acetate) | 99.1% | 2577.90 | 25 MG
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic that potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. It binds APC-ARM with a Ki value of 0.015 μM and a Kd value of 0.036 μΜ. This compound significantly represses the migration and invasion of colorectal cancer cells.
- Potently inhibits APC-Asef interaction
- Binds APC-ARM with a Ki value of 0.015 μM and a Kd value of 0.036 μΜ
- Significantly represses migration and invasion of colorectal cancer cells
- Reduces Asef-APC interaction in HEK293T cells
- Attenuates SW480 and HCT116 cell migration
- Decreases the active form of CDC42
Medchemexpress LLC Bradykinin acetate | 6846-03-3 | 99.58% | 1060.21 (free base) | 5 MG
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. It induces contraction of bronchial and intestinal non-vascular smooth muscle, increases vascular permeability, and participates in pain mechanisms. It is a potent vasodilator peptide that stimulates specific endothelial B2 receptors, causing the release of prostacyclin, NO, and EDHF.
- Effective endothelium-dependent vasodilator
- Lowers blood pressure
- Induces contraction of bronchial and intestinal non-vascular smooth muscle
- Increases vascular permeability
- Participates in pain mechanisms
- Stimulates specific endothelial B2 receptors
- Causes release of prostacyclin, NO, and EDHF
Medchemexpress LLC Lanreotide (acetate) | 2378114-72-6 | 99.8% | 1156.38 | 25 MG
Lanreotide (acetate) is a somatostatin analogue with antineoplastic activity, primarily used for the research of carcinoid syndrome. It has demonstrated effects on enhancing radiation-induced apoptosis and inhibiting GH-secreting pituitary adenoma cell proliferation and hormone release in vitro. In vivo studies showed tumor growth inhibition in GH3 tumor-bearing mice.
- Somatostatin analogue with antineoplastic activity
- Used for carcinoid syndrome research
- Enhances radiation-induced apoptosis
- Inhibits GH-secreting pituitary adenoma cell proliferation and hormone release
- Produces tumor growth inhibition in vivo
Medchemexpress LLC NN1213 acetate | 99.7% | 4553.10 | 5 MG
NN1213 acetate is a long-acting human amylin peptide analog and a selective Amylin receptor agonist. It effectively reduces food intake and fat mass, leading to a reduction in body weight in diet-induced obese rats. NN1213 acetate is intended for obesity research.
- Selective Amylin receptor agonist
- Reduces food intake and fat mass
- Reduces body weight in diet-induced obese rats
- Intended for obesity research
- Exhibits EC50 values of 0.177 nM for hAMY3R and 0.262 nM for rAMY3R
Cayman Chemical PentnoIc AcId-d9 100mg
An internal standard for the quantification of pentanoic acid by GC- or LC-MS
Medchemexpress LLC BMP-4 acetate | 99.3% | 1308.52 (free base) | 5 MG
BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. It regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages.
- Penetrating heparin-binding peptide
- Anti-inflammatory and anti-chondrogenic functions
- Regulates iNOS-IFN-IL6 signaling pathway
- Inhibits inflammatory proteins like iNOS, COX2, IFN, and IL6
- Alleviates arthritis symptoms in murine chondrocytes and macrophages
Cayman Chemical -a-Tocopherol Acetate 250g
An acetate form of (±)-α-tocopherol; inhibits heat-stress-induced decreases in blastocyst number in pregnant mice and GSH levels in isolated mouse zygotes in a model of hypothermia-induced pre-implantation embryonic death at 1 g/kg; prevents sidestream cigarette smoke-induced decreases in body weight and lung dynamic compliance and increases in lung resistance in mice at 1,050 IU/kg in the diet; increases IL-1β, IL-4, and IFN-γ levels in BALF in the same model
Apexbio Technology LLC L-NMMA acetate 53308-83-1 25mg
L-NMMA acetate (CAS 53308-83-1) is a broad-spectrum inhibitor of nitric oxide synthases (NOS) exerting inhibitory effects on neuronal (nNOS) endothelial (eNOS) and inducible (iNOS) isoforms It demonstrates submicromolar to low micromolar inhibitory activity against rat nNOS human eNOS and mouse iNOS By selectively blocking NOS-mediated nitric oxide production L-NMMA acetate is widely utilized for dissecting nitric oxide-dependent signaling pathways with research applications spanning studies of tissue injury inflammatory responses and cardiovascular system functions
Cambridge Isotope Laboratories Vitamin B1 pyrophosphate chloride (pyrimidyl-methyl-D3 98%) CP 95% 1 mg
Vitamin B1 pyrophosphate chloride (pyrimidyl-methyl-D3 98%) CP 95% 1 mg
Medchemexpress LLC Rel-PROTAC PARP1 degrader | 99.0% | 1145.09 | 10 MG
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand.
- Induces significant PARP1 cleavage.
- Induces programmed cell death.
- Inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM at 10 μM within 24 hours.
- For research use only.
Apexbio Technology LLC Retinyl (Vitamin A) Palmitate 79-81-2 10mM (in 1mL DMSO)
Retinyl Vitamin A Palmitate is a stabilized ester derivative of retinol (Vitamin A) and palmitic acid It is designed to deliver bioavailable Vitamin A upon enzymatic hydrolysis releasing free retinol that functions as an active intermediate in visual function cellular differentiation gene expression regulation and immune responses via retinoid receptors Retinyl Vitamin A Palmitate exerts its biological activity primarily through enzymatic hydrolysis generating retinol that participates in retinoid-mediated signaling pathways Based on these pharmacological properties Retinyl Vitamin A Palmitate holds research potential in studies of retinoid signaling vitamin deficiency models dermatological processes and nutritional supplementation evaluations
![Medchemexpress LLC 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- rel- | 99.0% | 1145.09 |...](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436876-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- rel- | 99.0% | 1145.09 |...
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
- Relative configuration of ROTAC PARP1 degrader
- Based on MDM2 E3 ligand
- Induces significant PARP1 cleavage
- Induces programmed cell death
- Appearance: solid
- Color: white to off-white
- Inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM at 10 μM at 24 h